A peptic ulcer is a sore on the lining of the stomach (gastric) or on a part of the small intestine called the duodenum (duodenal). It is a very common condition: one in ten Americans will develop an ulcer at some point in his or her life.

Ulcers were once thought to be the product of too much stress or too much spicy food. It is now known that a bacterium, Helicobacter pylori (H. pylori), is responsible for many peptic ulcers, which can be extremely painful.

Ulcers can also be caused by, among other things, the use of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs, such as aspirin and ibuprofen, are some of the most widely used drugs. NSAIDs can irritate the stomach and possibly cause ulcers.

Symptoms of ulcers vary based on the type of ulcer. When smptoms are present, they may include abdominal pain or discomfort, which is described as a dull, gnawing ache or burning that comes and goes for several days or weeks. Pain symptoms may improve or worsen in relation to meals and sleep, and may be relieved by antacids.

Treatment for some gastric and duodenal ulcers is available and can be very effective in healing and helping to prevent recurrence. However, symptom relief does not rule out a more serious condition.

TAP is committed to developing treatments and providing resources for patients who suffer from ulcers and other gastrointestinal conditions.